CALL FOR PAPERS Mitochondrial Function/Dysfunction in Health and Disease High doses of vitamin E improve mitochondrial dysfunction in rat hippocampus and frontal cortex upon aging
نویسندگان
چکیده
Ana Navarro,† Manuel J. Bandez, Jose M. Lopez-Cepero, Carmen Gómez, Alejandro D. Boveris, Enrique Cadenas, and Alberto Boveris Departments of Biochemistry and Molecular Biology, and Cell Biology and Histology, Faculty of Medicine, University of Cádiz, Cádiz, Spain; School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina; and Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California
منابع مشابه
High doses of vitamin E improve mitochondrial dysfunction in rat hippocampus and frontal cortex upon aging.
Rat aging from 4 to 12 mo was accompanied by hippocampus and frontal cortex mitochondrial dysfunction, with decreases of 23 to 53% in tissue and mitochondrial respiration and in the activities of complexes I and IV and of mitochondrial nitric oxide synthase (mtNOS) (P < 0.02). In aged rats, the two brain areas showed mitochondria with higher content (35-78%) of oxidation products of phospholipi...
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